Drug-induced Rosacea: A Systematic Review

Rosacea is a common cutaneous inflammatory disorder characterized by a heterogenous mix of features including erythema, papules, pustules, phymatous changes, telangiectasia and ocular manifestations, that may occur in response drug therapy. Documentation in the literature of drug-induced cases of rosacea, most commonly corticosteroid therapy, indicate that a potential rebound vasodilatory reaction from pro-inflammatory cytokine release may play a role in rosacea pathogenesis. Identifying and mitigating adverse events from drug therapy is important to treatment adherence in patients and to prevent unnecessary harm. This systematic review investigates the onset of rosacea in patients receiving drug therapy.玫瑰痤疮（Rosacea）是一种常见的皮肤炎性疾病，其临床特征具有异质性，可表现为红斑、丘疹、脓疱、肥厚性改变、毛细血管扩张及眼部表现，部分病例可由药物治疗诱发。现有文献中记载的药物诱导性玫瑰痤疮病例，以糖皮质激素治疗诱发者最为常见；相关研究表明，促炎性细胞因子释放所介导的反弹性血管扩张反应，可能参与玫瑰痤疮的发病机制。识别并缓解药物治疗引发的不良事件，对于保障患者的治疗依从性、避免不必要的机体损伤至关重要。本系统综述旨在探讨接受药物治疗的患者发生玫瑰痤疮的相关情况。