Cofilactin rod formation mediates inflammation-induced neurite degeneration.

Uruk et al. demonstrate that the brain inflammatory response causes neurite (axon and dendrite) degeneration by a mechanism involving NOX2-induced cofilactin rod (CAR) formation. Neurites are more vulnerable to Inflammation-induced injury than neuronal cell bodies, and neurite loss in the absence of neuronal cell body loss is associated with functional impairment.Uruk等人的研究证实，大脑炎症反应可通过涉及烟酰胺腺嘌呤二核苷酸磷酸氧化酶2（NOX2）诱导的丝切蛋白-肌动蛋白杆（cofilinactin rod，CAR）形成的机制，引发神经突（neurite，即轴突与树突）的变性。神经突相较于神经元胞体，对炎症诱导的损伤更为易感；且在神经元胞体未发生丢失的情况下出现的神经突丢失，与功能损害存在显著关联。