Transcriptomes of human monocytes from patients with familial hypercholesterolemia before and after statin treatment

Innate immune memory, also refered to as trained immunity (TRIM) is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components or metabolites. The cholesterol pathway is also involved in TRIM, and in this study we compared the transcriptomes of patients with hypercholesterolemia before and after statin treatment for 3 months. Overall design: Monocytes from healthy controls and patients with hypercholestoremia before and after 3 months of Statin treatment