Serum levels of inhaled APN01 and toxicokinetic parameters.

Dog serum samples were analyzed for levels of APN01 using ELISA. At scheduled blood sampling times (Days 1 and 14), serum was sampled from individual animals in Groups 3–5 and subsequently used to model toxicokinetic (TK) parameters. Reported TK parameters are: time at which maximum concentration was observed (Tmax), maximum concentration observed (Cmax), and area under the concentration curve at six hours (AUC6hr). Terminal phase parameters [e.g., T1/2] could not be calculated reliably for any of the profiles due to a lack of amenable data in the terminal phase of the profiles. Data for males and females are shown.