Effect of microtopography-induced nuclear constriction on chromatin accessibility in mesenchymal stromal cells in growth and osteogenic differentiation conditions.. Effect of microtopography-induced nuclear constriction on chromatin accessibility in mesenchymal stromal cells in growth and osteogenic differentiation conditions.

To investigate the influence of microtopography-induced constriction of cell nuclei on chromatin accessibility and gene expression in human mesenchymal stromal cells (hMSCs) Overall design: We then performed differential gene expression analysis using RNA-seq data & ATAC-Seq datasets for hMSCs cultured on flat and micropillar surfaces.