Individual actograms of wild type (A) and Hrh1-/- (B) mice.

Animals were housed for one week under LD12/12, then in DD for two weeks and finally for one week under LD12/12. The gray area corresponds to darkness. Analysis of locomotor activity by χ2-periodogram (C). Periodograms are plotted as 95% CI of means of a wild type (upper panel) and knockout (lower panel) mice under LD12/12 (light gray) or DD (dark gray) conditions, the horizontal solid line represents the Qp values at p = 0.01; n = 12 (wild type), 13 (Hrh1-/-). Cosinor analysis of locomotor activity under LD12/12 (D, upper panel) and DD (D, lower panel) regimes: black solid line show averaged locomotor activity over 48 h, black dashed line represents cosine fit for the averaged activity, light gray area show 95% CI of averaged activity. Analysis of activity fragmentation (E) under LD12/12 (upper panel) and DD (lower panel) regimes of wild type (light gray circles) and Hrh1-/- (black circles) animals.