Selection of dynamic biomarker candidates.

For selection of dynamic biomarker candidates, MFC, log2(MFC), P-value, and-log10(P-value) are summarized for each metabolite in the table. The majority of metabolites show a positive value for log2(MFC), where only two metabolites, namely carnitine (C0) and aspartic acid, show a negative value. Identical P-values, shown for some metabolites, result from the applied statistical test (Wilcoxon Signed Rank test for paired samples), which uses ranks for hypothesis testing. P-values are adjusted according to the false discovery rate (FDR) correction for multiple comparisons (see section Maximum fold changes and statistical hypothesis testing).
Selection of dynamic biomarker candidates.