Supplementary Material for: Clinical Features of Patients with Alzheimer’s Disease and a History of Traumatic Brain Injury

Introduction: Traumatic brain injury (TBI) has been associated with a greater risk of developing Alzheimer’s disease (AD). Less is known about the clinical features of AD patients with TBI history. The objective of this study was to examine whether a history of TBI and specific injury characteristics are associated with differences in age of disease onset, cognitive features, and neuropsychiatric symptoms (NPSs) in AD patients. Methods: Biomarker-proven AD patients (CSF or amyloid PET) were selected from the Amsterdam Dementia Cohort. TBI events were classified by age at injury (TBI

引言：脑外伤（TBI）与阿尔茨海默病（AD）的发病率增加有关。关于具有TBI病史的AD患者的临床特征所知甚少。本研究旨在探讨TBI病史及特定损伤特征是否与AD患者疾病发病年龄、认知特征以及神经精神症状（NPSs）存在差异。方法：从阿姆斯特丹痴呆队列中选取了生物标志物确诊的AD患者（脑脊液或淀粉样蛋白PET）。根据损伤年龄对TBI事件进行分类。