Association between depressive disorder, global seasonality score (GSS), and SNPs of the circadian clock genes in females from the Finnish population.

aSNPs yielding permutated pointwise p-values<0.05 in the single-locus analyses. bAllele: Major/Minor. c95% confidence intervals for the odds ratio (OR). dMinor allele frequency in non-overlapping groups of cases (D+) and controls(D–) stratified by the absence or presence of early morning awakening or fatigue. eThe P-values for GSS factor 1 (metabolic factor) and factor 2 (mental factor) association were generated using the linear regression model. Bold face SNP signify P-values<0.05, β (Regression coefficient) = −0.110. D+, patients with depression. D–, controls (no depression). D+EMA+, depressed patients with early morning awakening. D–EMA–, controls without early morning awakening. D+FAT+, depressed patients with fatigue. D–FAT–, controls without fatigue. *Permutation-based corrected empirical P = 0.0056 over the model D+FAT+ vs. D–FAT– when all examined variants (n = 106) were considered.