Influenza A PB2 (H357N mutation) in complex with VX-787

Influenza A PB2 (H357N mutation) in complex with VX-787 Descriptor: (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2 Authors: Radilova, K, Brynda, J. Deposit date: 2020-10-26 Release date: 2021-02-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural and Thermodynamic Analysis of the Resistance Development to Pimodivir (VX-787), the Clinical Inhibitor of Cap Binding to PB2 Subunit of Influenza A Polymerase. Molecules, 26, 2021

甲型流感病毒PB2（Polymerase basic protein 2，聚合酶碱性蛋白2）H357N突变体与VX-787的复合物。描述项：(2S,3S)-3-[[5-氟-2-(5-氟-1H-吡咯并[2,3-b]吡啶-3-基)嘧啶-4-基]氨基]双环[2.2.2]辛烷-2-羧酸、聚合酶碱性蛋白2。作者：拉迪洛娃（Radilova, K.）、布林达（Brynda, J.）。存档日期：2020-10-26；发布日期：2021-02-24；最后修改日期：2024-01-31。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.65埃（Å）。引用文献：《靶向甲型流感病毒聚合酶PB2亚基帽结合位点的临床抑制剂皮莫迪韦（VX-787）耐药性发展的结构与热力学分析》，发表于《分子》（Molecules）期刊，2021年，第26卷。