Distinct roles of PARP-1 and PARP-2 in c-Myc-driven B cell Lymphoma in mice

To study the implication of PARP-1 deficiency or PARP-2 deficiency in the development of c-Myc overexpression-induced B lymphomas, we have studied by RNAseq the gene expression profile in pre-B cells isolated from bone marrow of mice that overexpress c-Myc in their B lymphocytes (WT) and in those mice with PARP-1 (KO1) or PARP-2 (KO2) deficiency Overall design: 9 samples: 3 experimental groups with 3 biological replicates each: Wild type, Knock-Out Parp1, Knock-Out Parp2.