Proteomic Clustering Reveals the Kinetics of Disease Biomarkers in Bovine and Human Models of Post-Traumatic Osteoarthritis

Objectives: In this study, we applied a clustering method to two proteomic data sets from bovine (PRIDE PXD020756) and human models (this repository) of post-traumatic osteoarthritis (PTOA) to distinguish distinct clusters of proteins based on their kinetics of release from cartilage and examined these clusters for PTOA biomarker candidates. We quantified the effects of dexamethasone (Dex) on the kinetics of release of the cartilage media proteome.