Enantioselective Synthesis of Biaryl Atropisomers via Pd/Norbornene-Catalyzed Three-Component Cross-Couplings

Three-component cross-coupling cocatalyzed
by palladium and norbornene
is reported for the synthesis of biaryl atropisomers. This domino
reaction gave optimal yield and enantioselectivity with a P,C-type
ligand bearing axial chirality and P chiral center. The process showed
advantages over traditional cross-coupling because of its step economy
and its compatibility with readily available ortho-substituted aryl halides, which could, therefore, be used instead
of continuously trisubstituted aryl halides.