Agent-based models predict emergent behavior of heterogeneous cell populations in dynamic microenvironments: POPULATION HETEROGENEITY (4/5)

Data and results for `POPULATION HETEROGENEITY` simulations. Simulations of all possible combinations of four populations (X, A, B, C) under colony and tissue context with different levels of parameter heterogeneity (0, 0.1, 0.2, 0.3, 0.4, and 0.5). For tissue context, the healthy cell populations also varies parameter heterogeneity independent of the cancerous cell populations. Each condition is run for 15 days (21600 ticks) with 20 replicates (random seeds 0 - 19). Cells are introduced to the center of the constant source environment after a 1 day delay. Snapshots are taken every 0.5 days (720 ticks). The data folder contains .tar.xz compressed replicate sets. The data.param folder contains .tar.xz compressed replicate sets for .PARAM output. The results folder contains .pkl files of data parsed into arrays. Simulations are labeled as: [context]_[populations]_[population heterogeneity]_[background heterogeneity] - [context] - C = colony context, cancerous cell populations only - CH = tissue context, cancerous cell populations and healthy cells - [populations] - X = cancerous cell population with basal parameters - A = cancerous cell population with max_height x 1.5 - B = cancerous cell population with meta_pref x 1.5 - C = cancerous cell population with migra_threshold x 0.5 - [population heterogeneity] - ## = heterogeneity value for cancerous cell populations (##/10) - [background heterogeneity] - ## = heterogeneity value for healthy cell population (##/10) Additional data and results for this simulation set available at: - doi: 10.17632/bk9s769t3t - doi: 10.17632/mjpcm5my8z - doi: 10.17632/hskf9mxbpw - doi: 10.17632/p46dwfyvzg本数据集包含种群异质性（population heterogeneity）模拟的相关数据与实验结果。本模拟针对四种群体（X、A、B、C）的所有可能组合，在集落环境与组织环境下开展，参数异质性水平设置为0、0.1、0.2、0.3、0.4与0.5。在组织环境中，健康细胞群体的参数异质性变化与癌细胞群体相互独立。每个实验条件均运行15天（对应21600个时间步），并设置20次重复实验（随机种子取值0至19）。细胞会在1天延迟后被引入恒定源环境的中心位置。每间隔0.5天（对应720个时间步）采集一次系统快照。数据文件夹内存储.tar.xz压缩格式的重复数据集组；data.param文件夹内存储用于保存.PARAM输出文件的.tar.xz压缩重复数据集组；results文件夹内存储解析为数组格式的.pkl格式结果数据文件。模拟文件的命名格式为：[环境类型]_[种群组合]_[种群异质性水平]_[背景异质性水平]，其中：- 环境类型：C代表仅包含癌细胞群体的集落环境；CH代表包含癌细胞与健康细胞群体的组织环境；- 种群组合：X为采用基础参数的癌细胞群体；A为max_height放大1.5倍的癌细胞群体；B为meta_pref放大1.5倍的癌细胞群体；C为migra_threshold设置为原阈值0.5倍的癌细胞群体；- 种群异质性水平：##代表癌细胞群体的异质性数值（实际取值为##/10）；- 背景异质性水平：##代表健康细胞群体的异质性数值（实际取值为##/10）。本模拟集的额外数据与结果可通过以下DOI获取：- doi: 10.17632/bk9s769t3t- doi: 10.17632/mjpcm5my8z- doi: 10.17632/hskf9mxbpw- doi: 10.17632/p46dwfyvzg