five

Knee OA Functional Genomics

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NIAID Data Ecosystem2026-03-10 收录
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https://www.omicsdi.org/dataset/ega/EGAS00001001899
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The aim of this work is to apply an integrated systems approach to understand the biological underpinnings of knee osteoarthritis that culminates in the need for total joint replacement (TJR). This study is a feasibility pilot that integrates functional genomics data from diseased and non-diseased tissues of OA patients who have undergone TJR. For each tissue, we characterised epigenetic marks (methylation), gene transcription (RNASeq) and expression (quantitative proteomics). We also generated genotype data on the HumanCoreExome array for each individual.EGA study EGAS00001001899
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2017-07-26
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