Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing dihydrouracil (DHU)

Crystal structure of human NEIL1(P2G, E3Q, K242) bound to duplex DNA containing dihydrouracil (DHU) Descriptor: DNA (5'-D(*CP*GP*TP*CP*CP*AP*(UDH)P*GP*TP*CP*TP*AP*C)-3'), DNA (5'-D(*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*G)-3'), Endonuclease 8-like 1, ... Authors: Liu, M.H, Zhang, J, Zhu, C.X, Zhang, X.X, Gao, Y.Q, Yi, C.Q. Deposit date: 2020-02-07 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.83 Å) Cite: DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Nat Commun, 12, 2021

人类NEIL1（P2G、E3Q、K242）结合含二氢尿嘧啶（dihydrouracil, DHU）的双链DNA的晶体结构。描述项：DNA(5'-D(*CP*GP*TP*CP*CP*AP*(UDH)P*GP*TP*CP*TP*AP*C)-3')、DNA(5'-D(*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*G)-3')、内切核酸酶8样1（Endonuclease 8-like 1）等。作者：Liu M.H、Zhang J、Zhu C.X、Zhang X.X、Gao Y.Q、Yi C.Q。提交日期：2020-02-07；发布日期：2021-06-09；最后修改日期：2023-11-29。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.83埃（Å）。引用：DNA修复糖苷酶hNEIL1通过竞争性相互作用模式分选损伤碱基，《自然通讯》（Nat Commun），12卷，2021年。