Yeast cytosine deaminase (FCY1) deep mutational scanning

NIAID Data Ecosystem2026-03-13 收录

深度突变扫描

抗药性机制

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP347726 数据链接链接失效反馈

官方服务：

资源简介：

Examine the effects of all possible single amino acid substitutions on FCY1 (YPR062W) function and resistance to 5-FC (flucytosine).

创建时间：

2022-08-20

Fitness and functional landscapes of the E. coli RNase III gene rnc. Escherichia coli

蛋白质适应性

深度突变扫描

The relationships between protein sequence, protein structure, protein function, and organismal fitness are key to understanding the molecular basis for the fitness effects of mutations. How protein p

NIAID Data Ecosystem70

SeprotHub/Dataset-RASH_HUMAN

蛋白质突变预测

深度突变扫描

该数据集包含了人类RASH蛋白质单点突变及其对应的突变效应分数，这些分数来自于深度突变扫描实验。蛋白质的格式为氨基酸序列。数据集分为训练集、验证集和测试集，分别包含2479、338和317个样本。标签表示基于深度突变扫描实验的每个蛋白质的突变效应分数，范围从负无穷大到正无穷大，其中0代表野生型的值，数值越大表示适应性越高。

Hugging Face2025-05-13 更新70

Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

靶点验证

深度突变扫描

This record contains supplementary data files related to Deep mutational scanning to characterize the mechanistic role of TYK2 in immune signaling and disease, described below. - tyk2.bcmap-final.

Zenodo2025-10-13 更新40

Table B2 - Spearman’s correlations between DMS datasets generated by the same group

深度突变扫描

蛋白质功能分析

Source data for Figure 2.2. Spearman’s correlations between DMS datasets generated by the same research group. These alternative DMS datasets include altered selective conditions, different fitnes

NIAID Data Ecosystem70

Transfer frequency and specific assessment of conjugation.

细菌接合转移

抗药性机制

Note: a-the transfer requency was calculated by dividing the CFU of transconjugant by the CFU of donor;b- and c-the specificity of conjugation was assessed by the change of MIC and riboprint patterns

Figshare2015-12-02 更新40

Yeast cytosine deaminase (FCY1) deep mutational scanning

资源简介：

相关数据集