SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE100844
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We identified novel recurrent genetic lesions in T-PLL affecting genes involved in JAK/STAT signaling (PTPRC), epigenetic regulation (PRDM2), or DNA damage repair (SAMHD1, PARP10, HERC1, HERC2). Mutations of the tumor suppressor gene SAMHD1 causing amino-acid exchanges or protein truncations as well as copy number variations in SAMHD1 were seen in 20% of cases. Copy number variation analysis (Affymetrix SNP 6.0 and CytoHD Arrays) of 14 T-PLL patients.
创建时间：
2021-07-25
