Transcriptional profiling of C. neoformans H99 and mlc1- strain on CO2-independent medium at 37 °C. Cryptococcus neoformans var. grubii

The mlc1- deletion strain, derived from Cryptococcus neoformans var. grubii, H99 strain, has several phenotypes of interest, including loss of virulence, asymptomatic persistence in the brain and loss of capsule induction. All its in vitro phenotypes manifest in the CO2-independent medium at 37 °C, and we used this to compare its transcriptional profile relative to the parental strain.