HDAC enzyme activity for ACY-1083, Ricolinostat and Tubastatin A.

Figshare2022-10-12 更新2026-04-28 收录

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https://figshare.com/articles/dataset/HDAC_enzyme_activity_for_ACY-1083_Ricolinostat_and_Tubastatin_A_/21319666 数据链接链接失效反馈

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资源简介：

HDAC enzyme activity for ACY-1083, Ricolinostat and Tubastatin A.

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2022-10-12

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We disclose the first small molecule histone deacetylase (HDAC) inhibitor (3, BRD73954) capable of potently and selectively inhibiting both HDAC6 and HDAC8 despite the fact that these isoforms belong

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HDAC inhibition impedes epithelialâmesenchymal plasticity and suppresses metastatic, castration-resistant prostate cancer

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PI3K (phosphoinositide 3-kinase)/AKT and RAS/MAPK (mitogen-activated protein kinase) pathway coactivation in the prostate epithelium promotes both epithelialâmesenchymal transition (EMT) and metasta

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Computational Exploration of Zinc Binding Groups for HDAC Inhibition

HDAC抑制剂

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Histone deacetylases (HDACs) have emerged as important drug targets in epigenetics. The most common HDAC inhibitors use hydroxamic acids as zinc binding groups despite unfavorable pharmacokinetic prop

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HDAC enzyme activity for ACY-1083, Ricolinostat and Tubastatin A.

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