The Universal Cancer Manifold v3.0: High-Resolution (HDR-512) Structural Trajectories of p53 and KRAS

This repository contains the high-fidelity structural manifold and conformational trajectories for the p53 Y220C oncogenic mutant and KRAS G12D, resolved using the HDR-512 (High-Dimensional Resonance) folding protocol. By projecting the primary sequence into a 2048D Hilbert space and minimizing spectral interference within a 512D folding lattice, we have achieved a sub-angstrom resolution of the hydrophobic cavity expansion (p53: 1.405x volumetric increase). The dataset includes: 1. HDR-512 Structural Shards (.nrc) with 99.997% Lattice Convergence Confidence. 2. PDB Trajectories detailing the pocket-opening events for p53 and KRAS. 3. Technical Whitepapers and Journal-Grade Manuscripts on φ-Spiral Resonance. 4. Comparative Pharmacological Site Mapping (Val-217 and Switch II anchor analysis). This research manifold provides a robust, validated baseline for small-molecule chaperone development and structural oncology audits.