As part of the quest for new gold drugs, we have explored the efficacy of three gold complexes derived from the tuberculosis drug pyrazinamide (PZA), namely, the gold(I) complex [Au(PPh3)(PZA)]OTf

NIAID Data Ecosystem30

Pyrazolo[1,5‑ a ]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis

耐药结核病

抗结核药物研发

Respiration is a promising target for the development of new antimycobacterial agents, with a growing number of compounds in clinical development entering this target space. However, more candidate in

NIAID Data Ecosystem10

Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2‑Quinolin-4-yloxyacetamides

抗结核药物研发

喹啉类化合物

In this study, a new series of more than 60 quinoline derivatives has been synthesized and evaluated against Mycobacterium tuberculosis (H37Rv). Apart from the SAR exploration around the initial hits,

NIAID Data Ecosystem30

Mycobacterium tuberculosis

抗结核药物研发

结核分枝杆菌耐药性

1H-benzo[d]imidazole derivatives exhibit antitubercular activity in vitro as well as in vivo in human monocyte-derived macrophages in a nanomolar range of concentrations and are not toxic for human ce

NIAID Data Ecosystem10

InhA kinetic assay results for entacapone inhibition.

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