Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive gamma delta T cell repertoire

Repeated Plasmodium falciparum infections drive the development of clinical immunity to malaria in humans, however, the immunological mechanisms that underpin this response are only partially understood. We investigated the impact of repeated P. falciparum infections on human gamma delta T cell receipt in the context of natural infection in Malian children and adults, as well as serial controlled human malaria infection (CHMI) of U.S. adults, some of whom became clinically immune to malaria.