Chromatin accessibility regions in GC B cells during acute and chronic viral infection
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https://www.ncbi.nlm.nih.gov/sra/SRP298208
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To study how chronic viral infection disrupts B cell differentiation pathways and identify key intrinsic regulators in an endogenous polyclonal response, we used the comparative LCMV model. Wild-type mice were infected with either the acute (WE) versus chronic (Docile) strains of LCMV, GC B cells (CD19+IgDloCD95+CD38loCD138-) isolated 14 days post-infection, an ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) was undertaken. Overall design: 8 samples. Each group has at least 4 biological replicates.
创建时间:
2022-01-20



