We applied large-scale metabolomics followed by absolute quantification and machine learning-based feature selection using LASSO to identify metabolites that show a robust association with tumor biolo

NIAID Data Ecosystem40

The transcription factor BACH2 is required to establish immunosuppression within tumors

肿瘤抑制

BACH2转录因子功能

Through a diversity of functional lineages, cells of the innate and adaptive immune system either drive or constrain immune reactions within tumors. Thus, while the immune system has a powerful abilit

NIAID Data Ecosystem20

UTX condensation underlies its tumor suppressive activity

肿瘤抑制

表观遗传学

We investigated whether UTX condensates regulate local H3K4me1 in the genome by ChIP-seq of THP-1 cells expressing empty vector (control), UTX WT, ?cIDR, UTX-eIFIDR, or ?TPR. To determine the effect o

NIAID Data Ecosystem70

Additional file 2 of Integrative network analysis of circular RNAs reveals regulatory mechanisms for hepatic specification of human iPSC-derived endoderm

circRNA调控

细胞分化机制

Additional file 2. Appendix 2. Table S1: Upregulated and downregulated differentially expressed circRNAs during the hepatic specification.

NIAID Data Ecosystem30