Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor

Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor Descriptor: N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE, Vascular endothelial growth factor receptor 2 Authors: Harris, P.A, Cheung, M, Hunter, R.N, Brown, M.L, Veal, J.M, Nolte, R.T, Wang, L, Liu, W, Crosby, R.M, Johnson, J.H, Epperly, A.H, Kumar, R, Luttrell, D.K, Stafford, J.A. Deposit date: 2004-12-05 Release date: 2005-06-07 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors. J.Med.Chem., 48, 2005与2-苯胺基-5-芳基恶唑抑制剂结合的血管内皮生长因子受体2（VEGFR2）晶体结构 标识符：N-(环丙基甲基)-4-(甲氧基)-3-({5-[3-(3-吡啶基)苯基]-1,3-恶唑-2-基}氨基)苯磺酰胺 作者：Harris, P.A、Cheung, M、Hunter, R.N、Brown, M.L、Veal, J.M、Nolte, R.T、Wang, L、Liu, W、Crosby, R.M、Johnson, J.H、Epperly, A.H、Kumar, R、Luttrell, D.K、Stafford, J.A 存放日期：2004-12-05 发布日期：2005-06-07 最后修改日期：2024-02-14 实验方法：X射线衍射（分辨率2.1 Å） 引用文献：《2-苯胺基-5-芳基恶唑类作为新型VEGFR2激酶抑制剂的发现与评价》，《药物化学杂志》，第48卷，2005年