Paintfill analysis reveals inner ear morphological defects in Lrig mutants.

Inner ear morphology was assessed blind to genotype in animals with all possible combinations of Lrig1 and Lrig3 mutant alleles. “n” corresponds to the total number of ears that were scored for each genotype. Columns indicate the number of ears of each genotype that showed defects in the lateral canal, posterior canal, or saccule/utricle, with the percent of total ears examined in parentheses. Novel phenotypes were observed only in Lrig1−/−;Lrig3−/− double mutant animals.