Two Co(II)-based coordination polymers: structural diversity and treatment effect on the cardiac arrest induced by anesthesia by regulating <i>Sirt1</i> expression
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In the current study, two new Co(II)-containing coordination polymers (CPs) with the chemical formulae of {[Co(dimb)<sub>2</sub>(ndc)<sub>3</sub>]·2DMF}<sub>n</sub> (<b>1</b>) and {[Co<sub>2</sub>((R)-CBA)<sub>2</sub>(dimb)<sub>2</sub>](H<sub>2</sub>O)}<sub>n</sub> (<b>2</b>) have been successfully prepared by reaction of the N-donor ligand 1,3-di(1H-imidazol-1-yl)benzene (dimb) with the Co(NO<sub>3</sub>)<sub>2</sub>·6H<sub>2</sub>O and the different carboxylate ligands (1,4-naphthalenedicarboxylic acid (H<sub>2</sub>ndc) for <b>1</b> and 4-(1-carboxyethoxy)benzoic acid (H2CBA ) for <b>2</b>). Furthermore, the treatment effect of compounds <b>1</b> and <b>2</b> on the cardiac arrest induced by anesthesia was evaluated in the biological functional study. Firstly, the cardiac arrest-cardiopulmonary resuscitation animal model was constructed and compounds <b>1</b> and <b>2</b> were given for treatment at serious concentrations. The content of cardiac troponin T and B brain natriuretic peptide was measured with ELISA detection kit, and the RT-PCR was performed to detect the relative expression level of the <i>Sirt1</i> in the rat myocardial tissue after compounds treatment.
