<strong>Supplemental Table 4</strong>

Supplemental Table 4. Gut microbiome and metabolome after 7 days treatment of tacrolimus. A) Taxonomic assignment of gut microbiota was performed to compare to gut microbiota after 2 days of tacrolimus treatment. Gut metabolome after B) 2 days of tacrolimus was compared to gut metabolome after C) 7 days of treatment. To indicate the significantly affected pathways after 7 days of tacrolimus treatment, D) pathway enrichment analysis was performed using metabolite set enrichment analyses (MSEA) (Xia and Wishart, 2010). Metabolites of the intraluminal stool using CE/MS (capillary electrophoresis-mass spectrometry) (Kawamura et al., 2018; Matsumoto et al., 2014; Sugahara et al., 2017).