Framingham Heart Study Allelic Spectrum Sequencing Discovery

This substudy phs000307 Framingham Allelic Spectrum Project includes the generation of deep coverage targeted re-sequencing and variant identification for 216 genes in the Framingham Heart Study (FHS) sample collection, produced as part of NHLBI's Medical Resequencing projects. Summary level phenotypes for the Framingham Cohort study participants can be viewed at the top-level study page phs000007 Framingham Cohort. Individual level phenotype data and molecular data for all Framingham top-level study and substudies are available by requesting Authorized Access to the Framingham Cohort study phs000007. Cardiovascular disease (CVD) is the leading cause of death in the US, affecting 64 million Americans and costing over 368 billion dollars annually. To elucidate causes of CVD, NIH... (for more see dbGaP study page.)