PKA-S6K1 Chimera with compound 21a (CCT196539) bound

PKA-S6K1 Chimera with compound 21a (CCT196539) bound Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(6-bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-amine, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ... Authors: Couty, S, Westwood, I.M, Kalusa, A, Cano, C, Travers, J, Boxall, K, Chow, C.L, Burns, S, Schmitt, J, Pickard, L, Barillari, C, McAndrew, P.C, Clarke, P.A, Linardopoulos, S, Griffin, R.J, Aherne, G.W, Raynaud, F.I, Workman, P, Jones, K, van Montfort, R.L.M. Deposit date: 2013-08-21 Release date: 2013-10-09 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget, 4, 2013结合化合物21a（CCT196539）的PKA-S6K1嵌合体的结构描述项：(4S)-2-甲基-2,4-戊二醇、4-(6-溴-1-乙基-1H-咪唑并[4,5-c]吡啶-2-基)-1,2,5-恶二唑-3-胺、环腺苷酸依赖性蛋白激酶催化亚基α（CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA）…… 作者：Couty S、Westwood I.M、Kalusa A、Cano C、Travers J、Boxall K、Chow C.L、Burns S、Schmitt J、Pickard L、Barillari C、McAndrew P.C、Clarke P.A、Linardopoulos S、Griffin R.J、Aherne G.W、Raynaud F.I、Workman P、Jones K、van Montfort R.L.M 提交日期：2013-08-21 发布日期：2013-10-09 最后修改日期：2024-10-09 实验方法：X射线衍射（X-RAY DIFFRACTION，1.7 Å） 引用文献：《通过高通量筛选与结构导向药物设计发现强效核糖体S6激酶抑制剂》，《Oncotarget》，第4卷，2013年