Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [ChIP-seq]

EZH2 induces active transcription of the AR gene, thereby increasing AR level and promoting AR signaling. Importantly, EZH2-mediated activation of AR requires EZH2 protein occupancy at the AR gene promoter, but is independent of PRC2 as well as its histone methyltransferase activity ChIP-seq examination of EZH2 binding sites in LNCaP cells