Impact of simulation parameters on ‘bottleneck’ neuron survival characteristic (SSG R2), distance to seed survival characteristic (GDS R2), spread asymmetry (ASY) and time to network breakdown (TTNB).

Number of +/- signs indicate strength of impact on the metric compared to a baseline observation, with 0 indicating no impact. 1 N/A since initial protein seed concentrations were different (see Materials and methods; for similar seeds, TTNB would be much higher with soluble pathogenic protein). 2 The first three seeds had higher values. 3 Layer 4 and 5 seeds had lower values, whereas layer 6 had highest values. 4 *,* indicates the relationships: [tendency of pathogenic protein to avoid intercolumnar connections vs no spread selectivity], [tendency of pathogenic protein to spread via intercolumnar connections vs no spread selectivity].