Obesity promotes inflammatory, metabolic, and proliferative transcriptional programs in orthotopically transplanted murine colon tumors

The mechanisms driving obesity-associated colon cancer progression are not completely understood. This study leveraged RNA sequencing data from control and obese C57BL/6 mice to identify obesity-associated transcriptomic signatures. Bulk EpCAM+ epithelial tumor transcriptomic analyses revealed obesity-driven enrichment of inflammation, proliferation, and metabolic pathways. Overall design: RNAseq profiling of EpCAM+ epithelial tumor cells from orthotopically transplanted colon organoids in control and obese mice.