Discrimination of derived missense alleles by the NC statistic.
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Missense alleles are sub-classified info categories based on PolyPhen-2 predictions. Effect sizes were calculated as standard deviations from the mean of the NC statistic for synonymous variants at the same minor allele count (MAC). Within each MAC class, P-values were calculated by 1-sided Mann-Whitney test. Combined P-values for MAC 2–6 were computed by meta-analysis (Methods).
创建时间：
2013-02-28
