Relative crosstalk score.

For a particular gene i, the relative crosstalk score is calculated as the ratio of inter-pathway edge’s scores and the normalizing factor (E(i) ⋅ n(n-1)). where, n is the number of pathways considered in the study, and E(i) is the number of adjacent edges of node i. In this example n is equal to 2. Hence, n(n-1) = 2. (A) Gene A and gene B are connected to the genes of their respective pathways. This results in relative crosstalk score for both gene A and gene B to be zero. (B) Gene A is connected to gene B present in different pathways. In this case, there is only one edge between pathway A and pathway B. The crosstalk score (M) corresponding to this edge, for both the genes is 1. Normalizing factor both the genes is E(i) ⋅ n(n-1) = 3 ⋅ 2 = 6. Hence the relative crosstalk score is 1/6 for both the gene A and gene B.