Affinity of β-adrenoceptor ligands for the wildtype and polymorphic variants of the β1-adrenoceptor.

Log KD values obtained from 3H-CGP 12177 whole cell binding in cells expressing either the human wildtype β1-adrenoceptor or the polymorphic variants. KD values are mean ± s.e.mean for n separate experiments.
One-way ANOVA with post hoc Neuman-Keuls was performed comparing the affinities obtained for the wildtype receptor with those obtained for each polymorphic variant in turn.
# = p<0.05,
## = p<0.01,
### = p<0.001.
Statistically significant differences in affinities between the receptor polymorphisms were not seen in transiently transfected cells nor in all stable cell lines (Table S1 and S2 in File S1).
CGP 20712A (2-hydroxy-5-(2-[{hydroxy-3-(4-[1-methyl-4-trifluoromethyl-2-imidazolyl]phenoxy)propyl}amino]ethoxy)benzamide).
ICI 118551 ((-)-1-(2,3-[dihydro-7-methyl-1H-inden-4-yl]oxy)-3-([1-methylethyl]-amino)-2-butanol).