Supporting text.

Supporting information containing 1 additional table (Table A) with the numerical data depicted in Fig 3 and 4 additional Figures A, B, C and D explaining and reporting the results of computer simulations in which the full-state space and high mutation rates are considered. Details are provided regarding the effect of population size for different mutation rates and different error rates. The distribution over the full-state space is detailed, resorting to the representation of a simplex together with the most prevalent states. (PDF)