Profiling gene expression of the host response to an irradiated sporozoite immunization and Plasmodium vivax malaria challenge

We report an initial understanding of the modular immune response to a P. vivax malaria challenge after protection with PvRAS. By contrasting blood samples drawn at baseline, following immunization but pre-challenge, and at the first day of diagnosis of malaria in affected subjects. Overall design: RNA-seq analysis was performed for 20 individuals (5 Duffy Fy(-) and 15 Duffy Fy (+) from Cali Colombia) 3 Control, 5 Duffy Fy(-) and 12 PvRAS immunized for three of the time points, namely the diagnosis day, baseline and pre-challenge day.