Effect of dapagliflozin on urine metabolome in patients with type 2 diabetes

Abstract   

Context

Inhibitors of sodium-glucose cotransporters-2 have cardio- and renoprotective properties. However, the underlying mechanisms remain indeterminate.

Objective

To evaluate the effect of dapagliflozin on renal metabolism assessed by urine metabolome analysis in patients with type 2 diabetes.

Design

Prospective cohort study.

Setting

Outpatient diabetes clinic of a tertiary academic centre.

Patients

Eighty patients with HbA1c> 7% on metformin monotherapy were prospectively enrolled. 

Intervention

Fifty patients were treated with dapagliflozin for 3 months.  To exclude that the changes observed in urine metabolome were merely the result of the improvement in glycemia, 30 patients treated with insulin degludec were used for comparison.

Main Outcome Measure

Changes in urine metabolic profile before and after the administration of dapagliflozin and insulin degludec were assessed by Proton-Nuclear Magnetic Resonance spectroscopy (1H...