Mechanism underlying long-term visual dysfunction in the mouse model of oxygen-induced retinopathy

To investigate the mechanism of long-term visual dysfunction in the mouse model of oxygen-induced retinopathy (OIR) by performing RNA sequencing (RNA-seq) . Then further verify the results in transcriptional, expression and function, to explore the methods to improve its electrophysiological function and provide new ideas for the treatment of retinopathy of prematurity (ROP). 7 days C57BL/6 mice were placed in a closed hyperoxia chamber. After 5 days, they were raised in the ordinary air environment. On, the 17th day and 25th day, the eyes were removed. The results of RNA-seq in the retina of the OIR mice at P17 showed that compared with the normal control group, 102 differentially expressed genes were identified, of which 95 were significantly up-regulated and 7 were significantly down-regulated. This study provides a new idea of neuroprotection for the treatment of patients with mild premature retinopathy. Overall design: To investigate the mechanism of long-term visual dysfunction in the mouse model of oxygen-induced retinopathy by performing RNA sequencing (RNA-seq). 7 days C57BL/6 mice were placed in a closed hyperoxia chamber. After 5 days, they were raised in the ordinary air environment. On, the 17th day, the eyes were removed for RNA-seq.