Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (equatorial 4'-F)

Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (equatorial 4'-F) Descriptor: (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,4,6-trideoxy-4-fluoro-alpha-D-glucopyranoside, RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'), RNA (5'-R(P*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3') Authors: Kanazawa, H, Auffinger, P, Hanessian, S, Kondo, J. Deposit date: 2019-01-25 Release date: 2020-01-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Crystal structure of the bacterial ribosomal decoding site in complex with 4'-deoxy-4'-fluoro neamine analog (axial 4'-F) To Be Published

与4'-脱氧-4'-氟新霉胺类似物（赤道型4'-F）结合的细菌核糖体解码位点的晶体结构。结构描述符：(1R,2R,3S,4R,6S)-4,6-二氨基-2,3-二羟基环己基 2,6-二氨基-2,4,6-三脱氧-4-氟-α-D-吡喃葡萄糖苷，RNA(5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3')、RNA(5'-R(P*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3')。作者：Kanazawa H、Auffinger P、Hanessian S、Kondo J。沉积日期：2019-01-25；发布日期：2020-01-29；最后修改日期：2023-11-22。实验方法：X射线衍射（分辨率3.1 Å）。引用文献：与轴向4'-F构型4'-脱氧-4'-氟新霉胺类似物结合的细菌核糖体解码位点晶体结构【待发表】