Glutamine inhibited hyperglycolysis to curb lactylation of AMPKα to accelerate extracellular matrix synthesis and autophagy and restrain senescence in nucleus pulposus cell. Glutamine inhibited hyperglycolysis to curb lactylation of AMPKα to accelerate extracellular matrix synthesis and autophagy and restrain senescence in nucleus pulposus cell

IDD (Intervertebral disc degeneration) is an important cause of low back pain which has become a global public health problem. We aimed to determine the role of glutamine in the development of IDD and evaluate its mechanism to prevent IDD. Overall design: Nucleus pulposus cells and SD rats are devided into 3 group under the stimulation of control, TNF-α/puncture and glutamine