Crystal structure of the PI5P4Kbeta N203D-XTP complex

Crystal structure of the PI5P4Kbeta N203D-XTP complex Descriptor: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate Authors: Senda, M, Senda, T. Deposit date: 2021-04-13 Release date: 2022-03-30 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3.45 Å) Cite: The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity. Structure, 30, 2022PI5P4Kβ N203D-XTP复合物的晶体结构 描述：磷脂酰肌醇5-磷酸4-激酶2型β（Phosphatidylinositol 5-phosphate 4-kinase type-2 beta），[(2R,3S,4R,5R)-5-[2,6-二氧代-3H-嘌呤-9-基]-3,4-二羟基四氢呋喃-2-基]甲基膦酸氢酯，[[(2R,3S,4R,5R)-5-[2,6-二氧代-3H-嘌呤-9-基]-3,4-二羟基四氢呋喃-2-基]甲氧基-氧代膦基]膦酸氢酯 作者：Senda, M；Senda, T 提交日期：2021-04-13 发布日期：2022-03-30 最后修改日期：2023-11-29 实验方法：X射线衍射（3.45 Å） 引用文献：PI5P4Kβ的GTP应答性源自活性与特异性之间的妥协性权衡。《Structure》，第30卷，2022年