Massively Parallel Single-Cell RNA-Sequencing of Chronic Rhinosinusitis Nasal and Sinus Tissue

Eligibility criteria for subjects with AERD: History of AERD, defined as meeting the diagnostic triad with: History of physician-diagnosed asthma and History of physician-diagnosed nasal polyposis and History of pathognomonic reactions aspirin or other nonselective COX inhibitors. Eligibility criteria for aspirin-tolerant control subjects with nasal polyposis (CRSwNP): Physician-diagnosed nasal polyposis confirmed by nasal examination. No history of any adverse reaction to aspirin or a COX inhibitor. Exclusion Criteria: Individuals who meet any of these criteria were not eligible for enrollmentUse of any biologic agent within the 4 months prior to Screening. History of any sinonasal surgery within the 4 months prior to Screening. Current use of zileuton Current use of high-dose aspirin therapy. Past or current medical problems, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant’s ability to comply with study requirements or that may impact the quality of data obtained from the study.]]>