Classification by a gene expression profile can help to select oxaliplatin- or irinotecan-based regimen for first-line treatment of metastatic colorectal cancer: Translational research of the TRICOLORE study

The purpose of this study is to explore biomarkers related to clinical outcomes of OX and IRI as TR in the TRICOLORE trial, and a mutational analysis of colon-cancer-related genes, immunohistochemical staining, DNA methylation status, and a comprehensive gene expression analysis were performed as translational research (TR) Gene expression profile from 308 formalin-fixed and paraffin embedded primary tumor samples.