Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole

Crystal structure of human lanosterol 14alpha-demethylase (CYP51) in complex with econazole Descriptor: 1-[(2R)-2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, 1-[(2S)-2-[(4-CHLOROBENZYL)OXY]-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE, Cycloheptakis-(1-4)-(alpha-D-glucopyranose), ... Authors: Strushkevich, N, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Usanov, S.A, Park, H, Structural Genomics Consortium (SGC) Deposit date: 2009-09-15 Release date: 2010-03-02 Last modified: 2026-08-12 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis of human CYP51 inhibition by antifungal azoles. J. Mol. Biol., 397, 2010人源羊毛甾醇14α-去甲基化酶（CYP51）与益康唑（econazole）结合的晶体结构 描述信息：1-[(2R)-2-[(4-氯苄基)氧基]-2-(2,4-二氯苯基)乙基]-1H-咪唑、1-[(2S)-2-[(4-氯苄基)氧基]-2-(2,4-二氯苯基)乙基]-1H-咪唑、环七聚-(1→4)-α-D-吡喃葡萄糖（Cycloheptakis-(1-4)-(alpha-D-glucopyranose)）等 作者：Strushkevich N、MacKenzie F、Arrowsmith C.H.、Edwards A.M.、Bountra C、Weigelt J、Usanov S.A.、Park H，结构基因组学联合会（Structural Genomics Consortium, SGC） 提交日期：2009-09-15 发布日期：2010-03-02 最后修改日期：2023-09-06 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.9埃（Å）） 引用文献：抗真菌唑类化合物抑制人源CYP51的结构基础，《Journal of Molecular Biology》（J. Mol. Biol.），第397卷，2010年