Elevated cytokines induced by HPV contribute to potentiate the proliferation and angiogenesis required for lung tumorigenesis.
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HPV-related lung tumorigenesis is suggested to be associated with the up-regulation of anti-apoptotic Mcl-1 expression mediating by IL-6. In addition, HPV up-regulates IL-17 which subsequently promotes Mcl-1 expression bypassing the IL-17 downstream IL-6 molecules. HPV-induced IL-8 may act as an angiogenic factor which augments MMPs production and activities.
创建时间：
2016-02-24
