Crystal Structure of CK2alpha with N-(3-(((2-chloro-[1,1'-biphenyl]-4-yl)methyl)amino)propyl)methanesulfonamide bound

Crystal Structure of CK2alpha with N-(3-(((2-chloro-[1,1'-biphenyl]-4-yl)methyl)amino)propyl)methanesulfonamide bound Descriptor: 3-[[3-[3-[(3-chloranyl-4-phenyl-phenyl)methylamino]propylamino]-3-oxidanylidene-propanoyl]amino]benzoic acid, ACETATE ION, Casein kinase II subunit alpha, ... Authors: Brear, P, De Fusco, C, Georgiou, K, Iegre, J, Sore, H, Hyvonen, M, Spring, D. Deposit date: 2016-12-13 Release date: 2017-05-24 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.82 Å) Cite: A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066. Bioorg. Med. Chem., 25, 2017

结合N-(3-(((2-氯-[1,1'-联苯]-4-基)甲基)氨基)丙基)甲磺酰胺的CK2α晶体结构 描述符：3-[[3-[3-[(3-氯-4-苯基苯基)甲基氨基]丙基氨基]-3-氧代丙酰基]氨基]苯甲酸、乙酸根离子（ACETATE ION）、酪蛋白激酶IIα亚基（Casein kinase II subunit alpha）…… 作者：Brear P、De Fusco C、Georgiou K、Iegre J、Sore H、Hyvonen M、Spring D。入库日期：2016-12-13；发布日期：2017-05-24；最后修改日期：2024-01-17。实验方法：X射线衍射（X-RAY DIFFRACTION，1.82埃）。引用文献：基于片段的研究策略助力发现新型结合位点与选择性CK2抑制剂CAM4066，《Bioorg. Med. Chem.》，2017年，第25卷。