Mycobacterium tuberculosis variant bovis BCG Genome sequencing and assembly. Mycobacterium tuberculosis variant bovis BCG

5-fluorouracil (FU) is a well-known clinically approved chemotherapeutic agent whose metabolite, fluorodeoxyuridine monophosphate, irreversibly inhibits thymidylate synthase in cancer cells. Here we set out to identify the mechanism of resistance of FU and to determine whether it is a druggable target in vitro and in vivo.